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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC25C All Species: 16.36
Human Site: Y212 Identified Species: 40
UniProt: P30307 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P30307 NP_001781.2 473 53365 Y212 K V S R S G L Y R S P S M P E
Chimpanzee Pan troglodytes XP_001171027 473 53463 Y212 K V S R S G L Y R S P S M P E
Rhesus Macaque Macaca mulatta XP_001112750 472 53169 Y211 S V N R S C L Y R S P S M P E
Dog Lupus familis XP_853059 508 57301 Y247 S L N R S S L Y R S P S L P E
Cat Felis silvestris
Mouse Mus musculus P48967 447 50028 Q202 T T V P K L S Q N V K L E D Q
Rat Rattus norvegicus P48966 574 64268 F315 F S K C Q R L F R S P S M P C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507389 566 64832 M310 R L F R S P S M P S S A I R P
Chicken Gallus gallus
Frog Xenopus laevis P30309 550 62164 Y283 S L N R S R L Y R S P S M P E
Zebra Danio Brachydanio rerio NP_001108567 563 63619 L276 P L G M D S L L T A P L V A K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P20483 479 54076 P211 C F K R P E P P A S A N C S P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 95.7 74.6 N.A. 60.4 32.5 N.A. 31.7 N.A. 43.2 33.2 N.A. 26.2 N.A. N.A. N.A.
Protein Similarity: 100 99.3 97 81.6 N.A. 73.1 48.6 N.A. 49.4 N.A. 58.1 52.9 N.A. 44 N.A. N.A. N.A.
P-Site Identity: 100 100 80 66.6 N.A. 0 46.6 N.A. 20 N.A. 73.3 13.3 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 100 86.6 86.6 N.A. 6.6 53.3 N.A. 46.6 N.A. 86.6 40 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 10 10 10 10 0 10 0 % A
% Cys: 10 0 0 10 0 10 0 0 0 0 0 0 10 0 10 % C
% Asp: 0 0 0 0 10 0 0 0 0 0 0 0 0 10 0 % D
% Glu: 0 0 0 0 0 10 0 0 0 0 0 0 10 0 50 % E
% Phe: 10 10 10 0 0 0 0 10 0 0 0 0 0 0 0 % F
% Gly: 0 0 10 0 0 20 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % I
% Lys: 20 0 20 0 10 0 0 0 0 0 10 0 0 0 10 % K
% Leu: 0 40 0 0 0 10 70 10 0 0 0 20 10 0 0 % L
% Met: 0 0 0 10 0 0 0 10 0 0 0 0 50 0 0 % M
% Asn: 0 0 30 0 0 0 0 0 10 0 0 10 0 0 0 % N
% Pro: 10 0 0 10 10 10 10 10 10 0 70 0 0 60 20 % P
% Gln: 0 0 0 0 10 0 0 10 0 0 0 0 0 0 10 % Q
% Arg: 10 0 0 70 0 20 0 0 60 0 0 0 0 10 0 % R
% Ser: 30 10 20 0 60 20 20 0 0 80 10 60 0 10 0 % S
% Thr: 10 10 0 0 0 0 0 0 10 0 0 0 0 0 0 % T
% Val: 0 30 10 0 0 0 0 0 0 10 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 50 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _